Description: Scientists learn more about how immune system cells navigate through the human body on their way to fight disease. Credit: Daniel Irimia of Massachusetts General Hospital, and Monica Skoge and Albert Bae of the University of California, San Diego.
Description: As part of its commitment to encouraging future generations of scientists, NIGMS hosted an interactive web chat about the cell and careers in research for middle and high school students. https://publications.nigms.nih.gov/cellday2016/ Credit: NIGMS
Description: Northwestern University's Thomas O’Halloran studies the roles of metals in the body with a focus on how zinc regulates oocyte (egg cell) maturation and fertilization. His work could help us better understand infertility, cancer and certain bacterial infections. Credit: NIGMS
Description: Laura Kiessling describes the carbohydrate coat that covers the cells of all creatures on Earth, how cells use these coats to recognize one another, and how scientists can exploit this information to design new antimicrobials and new treatments for disease. Credit: NIGMS
Description: Time-lapse video of sigma B protein in bacterial cells reacting to stress. Appeared in Biomedical Beat—December 15, 2011 [https://publications.nigms.nih.gov/biobeat/11-12-15/#1]. Credit: Michael Elowitz Lab, California Institute of Technology.
Description: Scientists used cryo-electron microscopy to determine the structure of a dengue virus at a 3.5-Angstrom resolution. This animation reveals how the membrane proteins undergo major structural changes as the virus matures and infects a host. Appeared in Biomedical Beat—February 2, 2016 [https://biobeat.nigms.nih.gov/2016/02/cryo-electron-microscopy-reveals-molecules-in-ever-greater-detail/]. Credit: Hong Zhou, University of California, Los Angeles.
Description: This animation shows the effect of exposure to hypochlorous acid, which is found in certain types of immune cells, on bacterial proteins. The proteins unfold and stick to one another, leading to cell death. Appeared in Biomedical Beat—April 3, 2014 [https://biobeat.nigms.nih.gov/2014/04/bleach-vs-bacteria/]. Credit: American Chemistry Council. Full video at https://www.youtube.com/watch?v=TXyumLH_xAU.
Description: Sponsored by NIGMS, the Annual Biomedical Research Conference for Minority Students marked its 10th anniversary in 2010. A former NIGMS program director and students share their meeting experiences. Credit: NIGMS.
Description: Researchers created an apparatus to study quorum sensing, a communication system that allows some bacteria to cause dangerous infections. The bacteria multiply and begin quorum sensing (yellow). Appeared in Biomedical Beat—May 13, 2016 [https://biobeat.nigms.nih.gov/2016/05/cool-video-watching-bacteria-turn-virulent/]. Credit: Minyoung Kevin Kim and Bonnie Bassler, Princeton University.
Description: NIGMS grantee Dr. Scott Poethig, a plant biologist at the University of Pennsylvania, describes how he uses the history, culture and politics of food to excite others about science. Appeared in Biomedical Beat—September 29, 2014 [https://biobeat.nigms.nih.gov/2014/09/meet-scott-poethig/]. Credit: NIGMS.
Description: This animation shows the atoms that make up fibrinogen, a protein that helps form the flexible fibers that make up blood clots. Available on Computing Life [https://publications.nigms.nih.gov/computinglife/extras/bloodclot.html] online. Credit: Eric Lee, University of Illinois at Urbana-Champaign.
Description: Combining experiments with computer models, scientists simulate how calcium and calcium-regulating molecules move in 3-D inside a cell. Available on Computing Life [https://publications.nigms.nih.gov/computinglife/cells_circuits.htm]. Credit: Bridget Wilson, University of New Mexico.
Description: This animation shows the origin recognition complex (ORC), which recognizes and binds DNA to start replication, the process that copies the cell's genetic material prior to cell division. See the NIGMS Structural Biology Fact Sheet [https://www.nigms.nih.gov/education/pages/Factsheet_StructuralBiology.aspx] for related information. Credit: Huilin Li, Brookhaven National Laboratory and Bruce Stillman, Cold Spring Harbor Laboratory.
Description: This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Scientists determined the exact structure of the capsid and the proteins that it's made of using a variety of imaging techniques and analyses. They then entered this data into a supercomputer that produced the atomic-level image of the capsid. Appeared in Biomedical Beat—June 20, 2013 [https://publications.nigms.nih.gov/biobeat/13-06-20/#1]. Credit: Juan R. Perilla and the Theoretical and Computational Biophysics Group, University of Illinois at Urbana-Champaign.
Description: This video shows how structural biology provides insight into health and disease and is useful in developing new medications. Available on The Structures of Life [https://publications.nigms.nih.gov/structlife/] online. Credit: NIGMS.
Description: This animation shows how a microtubule, part of the cell's skeleton, builds and deconstructs. Appeared in Biomedical Beat—July 7, 2014 [https://biobeat.nigms.nih.gov/2014/07/cool-video-how-a-microtubule-builds-and-deconstructs/]. Credit: Eva Nogales lab, University of California, Berkeley.
Description: This animation shows how the proteasome breaks down damaged or unwanted proteins into bits that the cell can re-use to make new proteins. Appeared in Biomedical Beat—April 22, 2016 [https://biobeat.nigms.nih.gov/2016/04/the-proteasome-the-cells-trash-processor-in-action/]. Credit: Andreas Martin, University of California, Berkeley.
Description: Cytoplasmic linker protein (CLIP)-170 regulates microtubule dynamics and links microtubule ends to different intracellular structures. In this video, the gene for CLIP-170 has been fused with green florescent protein (GFP). When the protein is expressed in cells, the activities can be monitored in real time. Here, CLIP-170 streams toward the edges of the cell. See the NIGMS web page on Live Cell Imaging [https://www.nigms.nih.gov/Research/specificareas/cellimaging/Pages/livecellimaging.aspx] for related information. Credit: Gary Borisy, Marine Biological Laboratory.
Description: This time-lapse video shows how bacterial communities called biofilms can create blockages that prevent fluid flow in devices such as stents and catheters. Appeared in Inside Life Science—May 1, 2013 [https://publications.nigms.nih.gov/insidelifescience/biofilm-weave.html]. Credit: Knut Drescher, Princeton University.
Description: High school students Jasmine Johnson and Gabriel Vela discuss their experiences as researchers at The Jackson Laboratory. Appeared in Biomedical Beat—February 13, 2014 [https://biobeat.nigms.nih.gov/2014/02/]. Credit: NIGMS.
Description: NIGMS evolutionary geneticist, Dan Janes, answers questions about Charles Darwin and the role of evolution in health and biomedicine. For more information, read the Biomedical Beat blog post Evolution and Health: A conversation with evolutionary geneticist Dr. Dan Janes on the occasion of Charles Darwin’s birthday at https://biobeat.nigms.nih.gov/2016/02/evolution-and-health-charles-darwins-birthday/